全球信誉最好的网投平台

????時間：2月28日星期二16:00-17:30

Time：4:00-5:30?PM，Tuesday,?Feb.?28th，2023

主持人：西湖大學生命科學學院特聘研究員?徐和平

????Host：Dr.?Heping?Xu,?PI?of?School of Life Sciences

????地點：云谷校區E10-222

????Venue：E10-222,?Yungu?Campus

主講嘉賓/Speaker:

Dr.?Xiaoyu?Hu,?Professor and Director,?Institute of Immunology, Tsinghua University

Xiaoyu Hu received her Bachelor of Medicine degree from Peking University and obtained her Ph.D. degree in immunology from Cornell University. She held the position of tenure track Assistant Professor at Weill Cornell Medicine prior to joining Tsinghua University in 2014. Currently she is Professor at Institute for Immunology, Tsinghua University. ??

Dr. Hu's research aims to better understand molecular mechanisms governing functionality of two key cell types involved in host defense and inflammatory responses, macrophages and intestinal epithelial cells (IECs). One focus of Dr. Hu’s laboratory is to uncover transcriptional, translational and metabolic mechanisms that regulate macrophage and IEC responses to pathogenic and inflammatory cues. Dr. Hu’s work has been funded by agencies including National Natural Science Foundation of China (NSFC), Minister of Science and Technology of China, U.S. National Institutes of Health (NIH R01), U.K. Royal Society, American College of Rheumatology and Lupus Research Institute and has been reported by news media such as Time Online. ?

Dr. Hu has authored over 60 publications including corresponding-author research articles in journals such as Immunity, Nature Immunology, Cell Host & Microbe, Science Translational Medicine, Journal of Experimental Medicine, and Nature Communications and book chapters (h-index = 33). She is the recipient of multiple awards including Christina Fleischmann Award to Young Women Investigators from International Cytokine & Interferon Society, Distinguished Young Investigator Award from NSFC, Newton Advanced Fellowship from the U.K. Royal Society and Young Scholar Award from Arthritis Foundation. Dr. Hu also serves in editorial boards of journals including Science Advances, eLife, Trends in Immunology and composed commentary articles for journal such as Immunity. She actively advocates for status and rights of female scientists by serving in diversity panels for organizations such as Society of Leukocyte Biology and composing opinion essays for journals such as Nature Immunology.

講座摘要/Abstract:

Macrophages are tissue-resident immune cells that perform diverse functions, ranging from maintenance of tissue homeostasis to first-line host defense against pathogens. Meanwhile, malfunctions of macrophages contribute to pathogenesis of numerous human disease conditions including but not limited to acute and chronic inflammatory diseases, metabolic disorders and tumor. Thus, understanding key events and regulators governing macrophage functionality, especially in the context of tissue microenvironments, would deepen our understanding of basic macrophage biology and aid in designing therapeutic approaches targeting macrophages. Despite of tremendous progresses regarding pathways and molecules regulating macrophage activation and function, how macrophages adapt and respond to specific tissue environments in vivo in steady state and disease conditions remain surprisingly limited. I will share some examples of our preliminary thoughts on macrophage-tissue interactions although much work needs to be carried out in the future to consolidate various observations into a plausible conceptual framework.

聯系人/Contact：

生命科學學院

于文越?yuwenyue@trinapockett.com